Formulation and Drug Release of Isoxsuprine HCL Enteric Coated Tablets

( Vol-2,Issue-10,October 2016 )

Author(s): V. Nagamani

Total View : 1221
Downloads : 164
Page No: 1740-1745
DOI:

Keywords:

Double coated tablets, disintegration and dissolution studies, Enteric coated tablets, formulations, Isoxsuprine Hydrochloride.

Abstract:

The aim of the study is to formulate and evaluate enteric coated tablets using Isoxsuprine Hydrochloride as a model drug. Different core tablets and enteric coated tablets were prepared and drug release was studied. Isoxsuprine Hydrochloride core tablets were prepared by wet granulation method, using polymers, by changing drug ratios. The granules are evaluated for physical properties and the in-vitro drug release studies. Enteric coating was carried out using different sub coating materials. Enteric coating was performed in a mini coating pan at 107 rpm using low-pressure air atomized liquid spray technique. By changing the coating material, were done single coated, Double coated tablets are evaluated for uniformity hardness, friability, invitro disintegration and dissolution studies. The in-vitro drug release data was fitted into various kinetic models. All the formulations showed the values within the prescribed limit. It was observed that the higher rate and drug release was observed for the double coated tablets, this is because second layer having high viscosity.

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