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Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1,3-Dipolar Cycloaddition Reactions
( Vol-3,Issue-8,August 2017 )


Z. Tribak, M.K. Skalli, O. Senhaji, Y. Kandri. Rodi


Click cycloaddition, CuI, 1,4-disubstituted 1,2,3-triazoles, 1H NMR, 13C NMR.


A facile and simple protocol for the ‘Click’ cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained. Compared to the uncatalyzed cycloaddition, the yields are significantly improved in the presence of CuI as catalyst, without alteration of the selectivity. The regio- and stereochemistry of the cycloadducts has been corroborated by 1H, 13C NMR spectroscopy.

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